RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML
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چکیده
منابع مشابه
Hodgkin’s Lymphoma Occurring Secondary to Autologous Stem Cell Transplantation in Plasma Cell Leukemia; A Case Report
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OTT was first identified as part of the recurrent t(1;22) translocation in acute megakaryoblastic leukemia (AMKL) and was called OTT for “one twenty-two.” OTT1 is also known as RNA binding motif protein 15 (RBM15). Like other RNA binding motif proteins, RBM15 contains RNA recognition motifs (RRMs), 3 in total, which can bind to RNA and, at least for some RRMs, may also bind to DNA. Lifelong mai...
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created. Nevertheless, methods do exist to induce and expand natural Tregs in vitro, for example, with anti-CD3 TGF ,8 albeit the plasticity of these cells is a concern.9 The specificity of these Tregs needs to be tightly determined and controlled. Otherwise, we will be creating an expensive and nonspecific immunosuppressive cellular therapy. Despite these caveats, this model offers promise tha...
متن کاملConserved RNA secondary structures promote alternative splicing.
Pre-mRNA splicing is carried out by the spliceosome, which identifies exons and removes intervening introns. Alternative splicing in higher eukaryotes results in the generation of multiple protein isoforms from gene transcripts. The extensive alternative splicing observed implies a flexibility of the spliceosome to identify exons within a given pre-mRNA. To reach this flexibility, splice-site s...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2016
ISSN: 1934-5909
DOI: 10.1016/j.stem.2016.08.003